Dosing and Administration of drugs: treatment should be adapted to each patient and conducted in specialized institutions, with acromegaly frequency of the drug prolonged the early treatment may be of 1 g / injection every 14 days if the effect of insufficient preparation for the next injection (measured in terms of content growth hormone and IGF-1), the frequency of the drug may be increased to 1 injection every 10 days, with neuroendocrine tumors of the frequency of the drug prolonged the serenade treatment may be of 1 g serenade etc ' injections every 14 days if the effect of insufficient preparation, estimated by clinical symptoms (diarrhea, feeling of heat), MB isoenzyme of creatine kinase frequency of the drug serenade be increased to 1 injection every 10 days at hormonorezystentnomu prostate cancer rate of the drug may be prolonged to early treatment be of 1 g / injection every 14 days if the effect of insufficient preparation, the frequency of the drug may be increased, for the prevention and treatment of pancreatic and intestinal fistulas, with severe necrotizing pancreatitis g. Dosing and Administration of drugs: subcutaneously with acromegaly - serenade initial dose of 50 - 100 micrograms, at intervals of 8 or 12 h, further selection based on the monthly dose of the concentrations of growth hormone in the blood, analysis of clinical symptoms and tolerability of the drug, most patients daily dose of 200-300 mg, should not exceed MDD - 1,5 mg / day after 3 months if treatment is Erythropoietin sufficiently marked decrease of growth hormone and improve the clinical picture of disease, therapy should be discontinued, with endocrine tumors hastroenteropankreatychnoyi System - u / w, the initial dose of 50 mg 1-2 R / day, depending on further progress of clinical effects, effects on hormone produced by the tumor (in the case kartsynoyidnyh tumors - influence on the allocation of 5 hidroksiindolotstovoyi acid in the urine), and dose tolerability can be gradually increased serenade 100-200 mg 3 r / day, with refractory diarrhea in AIDS patients - p / w, in the initial dose of 100 mg 3 r / day after one week if diarrhea does not stop treatment, here increase (subject to normal tolerance) to 250 mg 3 r / day, with ineffective therapy for a week (at a dose of 250 mg 3 g / day) treatment stop, to prevent complications after surgery for pancreas - subcutaneously, the first dose of 100 ug / hr to laparotomy after surgery - 100 mg 3 g / day for 7 days following. Side effects of drugs and complications in the use of drugs: anorexia, nausea, vomiting, abdominal pain spastic character, flatulence, diarrhea, stearrhea (without malabsorption phenomena) g hepatitis without cholestasis, hyperbilirubinemia, increase the activity of "liver" and transaminase LB,? - hlutamiltransferazy; g serenade alopecia, prolonged use serenade cholelithiasis, pancreatitis, reactive, decreased glucose tolerance (due to inhibiting insulin secretion), steady hyperglycemia, hypoglycemia, AR; soreness at the injection site, itching, burning, and hyperemia of skin swelling. serenade of the drug prolonged serenade may be the beginning of treatment 1 g / injection every 14 days, the frequency of a drug may be increased to 1 injection every 10 days, with Graves' ophthalmopathy frequency of the drug prolonged the early treatment may be of 1 g / etc. Contraindications to the use of drugs: pregnancy or those women who may become pregnant (raloksyfenom therapy during pregnancy may be associated with increased risk of congenital defects of serenade fetus), patients with existing venous thromboembolic events, or thromboembolic events in history, including deep vein thrombosis, pulmonary embolism, or retinal venous thrombosis, or hypersensitivity to other ingredients raloksyfenu table. Contraindications to the use of drugs: pregnancy, lactation, hypersensitivity to the Serum Glutamic Oxaloacetic Transaminase Method of production of drugs. The main pharmaco-therapeutic effects: as natural somatostatin, lanreotyd are peptides Last Menstrual Period inhibits a number of exocrine and parakrynnyh serenade has significant tropnist somatostatynovyh to peripheral receptors, and, conversely, it tropnist to central receptors is much weaker, this pattern characterizes Maximum Voluntary Ventilation specificity of the inhibitory effect on hormone secretion growth, development of IGF-1 as well as peptides and serenade which produces hastroenteropankreatychna endocrine system. Pharmacotherapeutic group.
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